Intramitochondrial Ca(2+) Sensing by EMRE: The Matrix Outlook on Stimulus-Metabolism Coupling

David N Criddle; Alexei V Tepikin

doi:10.1016/j.molcel.2016.02.028

Intramitochondrial Ca(2+) Sensing by EMRE: The Matrix Outlook on Stimulus-Metabolism Coupling

Mol Cell. 2016 Mar 3;61(5):646-647. doi: 10.1016/j.molcel.2016.02.028.

Authors

David N Criddle¹, Alexei V Tepikin²

Affiliations

¹ Department of Cellular and Molecular Physiology and NIHR Liverpool Pancreas Biomedical Research Unit, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
² Department of Cellular and Molecular Physiology and NIHR Liverpool Pancreas Biomedical Research Unit, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK. Electronic address: a.tepikin@liverpool.ac.uk.

PMID: 26942668
DOI: 10.1016/j.molcel.2016.02.028

Abstract

Mitochondrial Ca(2+) entry is an important process regulating cellular bioenergetics, redox responses, and apoptosis. The study by Vais and colleagues (Vais et al., 2016), recently published in Cell Reports, describes a novel mechanism of modulating Ca(2+) entry that involves mitochondrial matrix Ca(2+).

Publication types

Comment

MeSH terms

Apoptosis
Calcium / metabolism*
Energy Metabolism
Humans
Mitochondria / metabolism*
Oxidation-Reduction

Substances

Calcium