Hijacking translation in addiction

Alicia Izquierdo; Alcino J Silva

doi:10.7554/eLife.14576

Hijacking translation in addiction

Elife. 2016 Mar 1:5:e14576. doi: 10.7554/eLife.14576.

Authors

Alicia Izquierdo¹, Alcino J Silva²

Affiliations

¹ Department of Psychology, the Brain Research Institute, the Integrative Center for Learning and Memory, and the Integrative Center for Addictions, University of California Los Angeles, Los Angeles, United States.
² Departments of Psychology, Neurobiology and Psychiatry, the Brain Research Institute, and the Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, United States.

Abstract

Two studies suggest that the reduced activity of a translation initiation factor called eIF2α might be partly responsible for the increased risk of drug addiction seen in adolescents.

Keywords: cocaine; human; mouse; neuroscience; nicotine-induced plasticity; protein synthesis; ventral tegmental area.

Publication types

Comment

MeSH terms

Cocaine*
Humans
Ventral Tegmental Area*

Substances

Cocaine