Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients

Hamdy Moselhy; Valsamma Eapen; Nadia A Akawi; Ali Younis; Badr Salih; Aws R Othman; Said Yousef; Raymond A Clarke; Bassam R Ali

doi:10.1016/j.mgene.2015.07.002

Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients

Meta Gene. 2015 Jul 21:5:135-9. doi: 10.1016/j.mgene.2015.07.002. eCollection 2015 Sep.

Authors

Hamdy Moselhy¹, Valsamma Eapen², Nadia A Akawi³, Ali Younis⁴, Badr Salih⁴, Aws R Othman³, Said Yousef¹, Raymond A Clarke⁵, Bassam R Ali³

Affiliations

¹ Department of Psychiatry, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.
² University of New South Wales, Australia; Ingham Institute, School of Medicine, University of Western Sydney, Sydney, NSW, Australia.
³ Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.
⁴ Al-Ain Hospital, Al-Ain, United Arab Emirates.
⁵ Ingham Institute, School of Medicine, University of Western Sydney, Sydney, NSW, Australia.

Abstract

Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes.

Keywords: DISC1; Genetics; NRG3; PDLIM5; PICK1; Schizophrenia.