Long-term survival of patients with multidrug-resistant tuberculosis according to treatment outcomes

Nakwon Kwak; Chul-Gyu Yoo; Young Whan Kim; Sung Koo Han; Jae-Joon Yim

doi:10.1016/j.ajic.2016.01.012

Long-term survival of patients with multidrug-resistant tuberculosis according to treatment outcomes

Am J Infect Control. 2016 Jul 1;44(7):843-5. doi: 10.1016/j.ajic.2016.01.012. Epub 2016 Feb 26.

Authors

Nakwon Kwak¹, Chul-Gyu Yoo¹, Young Whan Kim¹, Sung Koo Han¹, Jae-Joon Yim²

Affiliations

¹ Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
² Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: yimjj@snu.ac.kr.

PMID: 26922891
DOI: 10.1016/j.ajic.2016.01.012

Abstract

Survival times of 219 patients diagnosed with multidrug-resistant tuberculosis were calculated and treatment outcomes compared. Mean survival of 20 patients who failed to be cured was 109.8 months (95% confidence interval [CI], 87.4-132.1), shorter than that of 150 patients who were cured (140.4 months; 95% CI, 136.1-144.7; P < .01) and that of 28 patients classified as treatment completed (138.5 months; 95% CI, 131.0-146.1; P = .02). The results demonstrate that patients with multidrug-resistant tuberculosis with poor treatment outcomes live 9 years, on average.

Keywords: Mean survival time; Mortality; Transmission; Treatment failure.

MeSH terms

Adult
Antitubercular Agents / therapeutic use*
Female
Humans
Male
Middle Aged
Survival Analysis
Treatment Outcome
Tuberculosis, Multidrug-Resistant / mortality*

Substances

Antitubercular Agents