EMT: Matter of Life or Death?

Sonal Gupta; Anirban Maitra

doi:10.1016/j.cell.2016.02.024

EMT: Matter of Life or Death?

Cell. 2016 Feb 25;164(5):840-2. doi: 10.1016/j.cell.2016.02.024.

Authors

Sonal Gupta¹, Anirban Maitra²

Affiliations

¹ Sheikh Ahmed Pancreatic Cancer Research Center, Departments of Pathology and Translational Molecular Pathology, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
² Sheikh Ahmed Pancreatic Cancer Research Center, Departments of Pathology and Translational Molecular Pathology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: amaitra@mdanderson.org.

PMID: 26919422
DOI: 10.1016/j.cell.2016.02.024

Abstract

TGF-β is long considered a "protean" cytokine in cancer, changing its role from anti- to pro-tumorigenic in a context-dependent manner. In this issue of Cell, David et al. use mouse models of pancreatic cancer to shed light on the mechanistic basis of how TGF-β-induced EMT is coupled to either apoptosis or tumor progression.

Publication types

Comment

MeSH terms

Animals
Carcinoma, Ductal / genetics*
Epithelial-Mesenchymal Transition*
Gene Regulatory Networks*
Pancreatic Neoplasms / genetics*
Transforming Growth Factor beta / antagonists & inhibitors*

Substances

Transforming Growth Factor beta