Formation and characterization of pseudo-polyrotaxanes based on poly(p-dioxanone) and cyclodextrins

Carbohydr Polym. 2016 May 20:142:82-90. doi: 10.1016/j.carbpol.2016.01.034. Epub 2016 Jan 16.

Abstract

Novel pseudo-polyrotaxanes (PPRs) consisting of poly(p-dioxanone) (PPDO) and cyclodextrins (CDs) were obtained via heat-cool (H-C) cycles. The optimum preparation condition for achieving the highest yield was investigated, which was selected as follow: 3 times H-C cycles in 72 h of PPDO and CDs dissolved in DMF at 60 °C. The PPRs were further characterized by using wide-angle X-ray diffraction (WAXD), NMR, FT-IR, and thermogravimetric analysis (TGA). It was found that PPDO could be wrapped by CDs units. Compare to the single PPDO chain, the PPRs have better thermal stability. Moreover, the hydrophilicity of PPRs is also enhanced significantly determined by the water static contact angle tests. In addition, hydrolytic degradation experiments showed that the PPRs had unique degradation behaviors. The construction of the PPRs based on the PPDO and CDs would further expand the application of PPDO as biomaterials.

Keywords: 1,4-Dioxan-2-one (PubChem CID: 18233); Cyclodextrin; Degradation; Hydrophilicity; Poly(p-dioxanone); Pseudo-polyrotaxanes; α-Cyclodextrin (PubChem CID: 444913); β-Cyclodextrin (PubChem CID: 444041); γ-Cyclodextrin (PubChem CID: 5287407).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cold Temperature
  • Cyclodextrins / chemistry*
  • Dioxanes / chemistry*
  • Hot Temperature
  • Hydrolysis
  • Hydrophobic and Hydrophilic Interactions
  • Magnetic Resonance Spectroscopy
  • Polymers / chemistry*
  • Rotaxanes / chemistry*
  • Spectroscopy, Fourier Transform Infrared
  • Thermogravimetry
  • X-Ray Diffraction

Substances

  • Cyclodextrins
  • Dioxanes
  • Polymers
  • Rotaxanes
  • poly-4-dioxan-2-one