Mantle cell lymphoma (MCL) is a rare aggressive lymphoid neoplasm occurring in approximately 3% to 10% of non-Hodgkin lymphomas. Renal involvement is rarely reported in case of MCL. We hereby described a case of MCL in a 76-year-old man in whom bilateral renal involvement was detected on FDG PET/CT. The patient underwent chemotherapy, and follow-up PET/CT reveals resolution of the renal lesions.