Neurohypophyseal Hormones: Novel Actors of Striated Muscle Development and Homeostasis

Alessandra Costa; Eleonora Rossi; Bianca Maria Scicchitano; Dario Coletti; Viviana Moresi; Sergio Adamo

doi:10.4081/ejtm.2014.3790

Neurohypophyseal Hormones: Novel Actors of Striated Muscle Development and Homeostasis

Eur J Transl Myol. 2014 Sep 22;24(3):3790. doi: 10.4081/ejtm.2014.3790. eCollection 2014 Sep 23.

Authors

Alessandra Costa¹, Eleonora Rossi², Bianca Maria Scicchitano³, Dario Coletti¹, Viviana Moresi², Sergio Adamo¹

Affiliations

¹ (1) Histology and Medical Embryology Section, Dept. AHFMO, Sapienza University, Rome, Italy; (2) I.I.M., Interuniversity Institute of Myology.
² (1) Histology and Medical Embryology Section, Dept. AHFMO, Sapienza University , Rome, Italy.
³ (1) Histology and Medical Embryology Section, Dept. AHFMO, Sapienza University, Rome, Italy; (2) I.I.M., Interuniversity Institute of Myology; (3) Institute of Histology and Embryology, Catholic University School of Medicine, Rome, Italy.

Abstract

Since the 1980's, novel functional roles of the neurohypophyseal hormones vasopressin and oxytocin have emerged. Several studies have investigated the effects of these two neurohormones on striated muscle tissues, both in vitro and in vivo. The effects of vasopressin on skeletal myogenic cells, developing muscle and muscle homeostasis have been documented. Oxytocin appears to have a greater influence on cardiomyocite differentiation and heart homeostasis. This review summarizes the studies on these novel roles of the two neurohypophyseal hormones, and open the possibility of new therapeutic approaches for diseases affecting striated muscle.

Keywords: Arginine-vasopressin; oxytocin; receptors and signal transduction mechanisms; skeletal myogenic cells and cardiomyocite differentiation and homeostasis.

Publication types

Review