Wide-field optical coherence tomography based microangiography for retinal imaging

Sci Rep. 2016 Feb 25:6:22017. doi: 10.1038/srep22017.

Abstract

Optical coherence tomography angiography (OCTA) allows for the evaluation of functional retinal vascular networks without a need for contrast dyes. For sophisticated monitoring and diagnosis of retinal diseases, OCTA capable of providing wide-field and high definition images of retinal vasculature in a single image is desirable. We report OCTA with motion tracking through an auxiliary real-time line scan ophthalmoscope that is clinically feasible to image functional retinal vasculature in patients, with a coverage of more than 60 degrees of retina while still maintaining high definition and resolution. We demonstrate six illustrative cases with unprecedented details of vascular involvement in retinal diseases. In each case, OCTA yields images of the normal and diseased microvasculature at all levels of the retina, with higher resolution than observed with fluorescein angiography. Wide-field OCTA technology will be an important next step in augmenting the utility of OCT technology in clinical practice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diabetic Retinopathy / diagnosis
  • Female
  • Fluorescein Angiography*
  • Humans
  • Male
  • Microvessels
  • Middle Aged
  • Retina / pathology
  • Retinal Diseases / diagnosis*
  • Retinal Vessels*
  • Retinitis Pigmentosa / diagnosis
  • Tomography, Optical Coherence*