Chromosomes at loose ends

Nat Cell Biol. 2016 Mar;18(3):257-9. doi: 10.1038/ncb3321.

Abstract

Broken ends of a budding yeast chromosome exhibit increased mobility, presumably to facilitate repair by recombination. A new study reports that increased mobility reflects the untethering of the broken chromosome, triggered by a DNA damage response that phosphorylates the Cep3 kinetochore protein and weakens the association between the centromere and the spindle pole body.

Publication types

  • Comment

MeSH terms

  • Centromere / metabolism*
  • Chromatin / metabolism*
  • DNA Repair / genetics*
  • DNA-Binding Proteins / metabolism*
  • Kinetochores / metabolism*
  • Nuclear Proteins / metabolism*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism*

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins