Preeclampsia and future cardiovascular risk: A point of view from the clearance of plasma vasoactive amines

Hypertens Pregnancy. 2016;35(1):1-14. doi: 10.3109/10641955.2015.1115062. Epub 2016 Feb 24.

Abstract

Objective: To summarize the reported evidence on the relationship between vasoactive amines and preeclampsia.

Methods: A literature search was conducted in MEDLINE/PubMed and EMBASE.

Results: The summarized results are as follows: (1) Menstruation can effectively eliminate vasoactive amines norepinephrine, serotonin and histamine. (2) Pregnancy increases norepinephrine production due to fetal brain development and decreases vasoactive-amine elimination due to amenorrhea. (3) Preeclampsia is associated with a low renal and/or sweating capacity, or in rare cases, with increased norepinephrine production due to maternal pheochromocytoma and fetal neuroblastoma.

Conclusion: Preeclampsia is mainly due to decreased excretion of norepinephrine and other vasoactive amines.

Keywords: Cardiovascular risk; gestational hypertension; norepinephrine; preeclampsia; vasoactive amines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / etiology*
  • Female
  • Histamine / blood*
  • Humans
  • Menstruation / blood
  • Norepinephrine / blood*
  • Pre-Eclampsia / blood*
  • Pregnancy
  • Risk Factors
  • Serotonin / blood*

Substances

  • Serotonin
  • Histamine
  • Norepinephrine