A GPCR Handles Bacterial Sensing in Chemotaxis and Phagocytosis

Hiroshi Senoo; Hiromi Sesaki; Miho Iijima

doi:10.1016/j.devcel.2016.02.006

A GPCR Handles Bacterial Sensing in Chemotaxis and Phagocytosis

Dev Cell. 2016 Feb 22;36(4):354-6. doi: 10.1016/j.devcel.2016.02.006.

Authors

Hiroshi Senoo¹, Hiromi Sesaki¹, Miho Iijima²

Affiliations

¹ Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: miijima@jhmi.edu.

Abstract

In this issue of Developmental Cell, Pan et al. (2016) identified in cells of the social amoeba Dictyostelium a G protein-coupled receptor (GPCR) that recognizes a chemoattractant secreted by bacteria. This work uncovers a mechanism by which a single GPCR mediates pseudopod extension during cell migration and bacterial engulfment.

Publication types

Comment

MeSH terms

Animals
Chemotaxis / physiology*
Dictyostelium / metabolism*
Folic Acid / metabolism*
Phagocytosis / physiology*
Receptors, G-Protein-Coupled / metabolism*

Substances

Receptors, G-Protein-Coupled
Folic Acid

Grants and funding

R01 GM084015/GM/NIGMS NIH HHS/United States