Interleukin-1β Can Reduce Manifestations of Delayed Effects of Prolonged Exposure to Low-Intensity γ-Radiation

Bull Exp Biol Med. 2016 Feb;160(4):470-3. doi: 10.1007/s10517-016-3199-3. Epub 2016 Feb 23.

Abstract

We showed that injection of IL-1β (Betaleukin) in a dose of 3 μg/kg 22 h before prolonged (21 h) exposure to low-intensity (10 mGy/min) γ-radiation in a dose of 12.6 Gy reduced the number of double-strand DNA breaks in murine spleen cells to the control level in 4 months after exposure and the number of double-strand DNA breaks induced by additional acute irradiation in a dose of 6 Gy. The results suggest that IL-1β can improve the efficiency of systems reducing the number of double-strand DNA breaks in murine spleen cells at delayed terms after exposure to prolonged low-intensity radiation.

Keywords: delayed effects of radiation; double-strand DNA breaks; interleukin-1β; low dose rate; γ-radiation.

MeSH terms

  • Animals
  • DNA / radiation effects*
  • DNA Breaks, Double-Stranded / drug effects*
  • DNA Breaks, Double-Stranded / radiation effects*
  • DNA Repair / drug effects*
  • Gamma Rays / adverse effects*
  • Interleukin-1beta / pharmacology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Spleen / cytology

Substances

  • IL1B protein, mouse
  • Interleukin-1beta
  • DNA