Abstract
Silkworm shows hyperglycemia after intake of diet containing large amount of glucose. The hyperglycemic silkworm model is useful for evaluation of anti-diabetic drugs. A hot water extract of Rehmanniae Radix, an herbal medicine, showed hypoglycemic effect against the hyperglycemic silkworms. This method is applicable for quick and simple evaluation of the hypoglycemic activities of different batches of Rehmanniae Radix. Our findings suggest that silkworms have a lot of merit as experimental animals for evaluation of various herbal medicines.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bombyx / drug effects*
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Bombyx / embryology
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Bombyx / metabolism
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Diabetes Mellitus / drug therapy*
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Diabetes Mellitus / metabolism
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Disease Models, Animal
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Drug Discovery / methods*
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Glucose / metabolism*
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Humans
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / pharmacology*
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Larva / drug effects
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Larva / metabolism
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Phytotherapy
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plants, Medicinal
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Rehmannia / chemistry*
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Species Specificity
Substances
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Hypoglycemic Agents
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Plant Extracts
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Glucose