Comparative Analysis of the Proliferative Potential of Human Mesenchymal Stromal Cells from Extraembryonic Organs, Endometrium, and Adipose Tissue

Bull Exp Biol Med. 2016 Feb;160(4):548-54. doi: 10.1007/s10517-016-3216-6. Epub 2016 Feb 23.

Abstract

Proliferative activity of mesenchymal stromal cells isolated from five sources (chorionic villi, Wharton's jelly, amnion, endometrium, and adipose tissue) was compared by flow cytometry and real-time PCR (by the content of mRNA of genes encoding of cell cycle regulators). Mesenchymal stromal cells derived from the endometrium demonstrated maximum stability and high proliferative potential.

Keywords: apoptosis; multipotent mesenchymal stromal cells; proliferation; umbilical cord.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / cytology*
  • Adult
  • Amnion / cytology*
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Chorionic Villi / growth & development*
  • Endometrium / cytology*
  • Female
  • Flow Cytometry
  • Humans
  • Mesenchymal Stem Cells / cytology*
  • Real-Time Polymerase Chain Reaction
  • Wharton Jelly / cytology*
  • Young Adult