Therapeutic Potential of Neuregulin in Cardiovascular System: Can we Ignore the Effects of Neuregulin on Electrophysiology?

Mini Rev Med Chem. 2016;16(11):867-71. doi: 10.2174/1389557516666160223122039.

Abstract

Neuregulin-1(NRG-1) has now been accepted to have therapeutic potential in cardiovascular disease. The preclinical and clinical researches of NRG-1 have demonstrated its advantage effects in cardiac function with multi-target cardiovascular biology and pathophysiology, but its influence on cardiac electrophysiology is rarely involved, which is a very important aspect and should not be ignored.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / physiopathology*
  • Death, Sudden, Cardiac / etiology
  • Electrophysiology
  • Genetic Variation
  • Heart / drug effects*
  • Heart / innervation
  • Heart / physiopathology*
  • Humans
  • Ion Transport / drug effects
  • Myocardium / metabolism
  • Neuregulin-1 / genetics
  • Neuregulin-1 / metabolism*
  • Neuregulin-1 / therapeutic use*
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism
  • Recombinant Proteins / therapeutic use

Substances

  • NRG1 protein, human
  • Neuregulin-1
  • Recombinant Proteins