1 Departments of Pediatrics and Obstetrics & Gynecology, The Ohio State University Wexner Medical Center and The Center for Perinatal Research and the Heart Center at Nationwide Children's Hospital, Columbus, Ohio Department of Obstetrics & Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio Seattle Children's Research Institute, University of Washington School of Medicine, Seattle, Washington Department of Pediatrics, The Ohio State University Wexner Medical Center and The Center for Perinatal Research and the Research Institute at Nationwide Children's Hospital, Columbus, Ohio.