Abstract
Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from eIF4E to allow cap-dependent translation to proceed. Recently, 4E-BP1 was shown to be phosphorylated by other kinases besides mTOR, and overexpression of 4E-BP1 was found in different human carcinomas. In this review, we summarize the novel findings on mTOR independent 4E-BP1 phosphorylation in carcinomas. The implications of overexpression and possible multi-function of 4E-BP1 are also discussed.
Keywords:
cancer; eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1; kinase; mTOR; overexpression; phosphorylation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics*
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Adaptor Proteins, Signal Transducing / metabolism
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Cell Cycle Proteins
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Gene Expression Regulation, Neoplastic*
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Humans
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / genetics
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / metabolism
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Mechanistic Target of Rapamycin Complex 1
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Mitogen-Activated Protein Kinases / genetics*
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Mitogen-Activated Protein Kinases / metabolism
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Multiprotein Complexes / genetics
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Multiprotein Complexes / metabolism
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Neoplasms / genetics*
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Neoplasms / metabolism
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Neoplasms / pathology
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Peptide Chain Initiation, Translational*
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Phosphoproteins / genetics*
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Phosphoproteins / metabolism
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Phosphorylation
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Regulatory-Associated Protein of mTOR
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Signal Transduction
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TOR Serine-Threonine Kinases / genetics
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TOR Serine-Threonine Kinases / metabolism
Substances
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Adaptor Proteins, Signal Transducing
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Cell Cycle Proteins
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EIF4EBP1 protein, human
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Multiprotein Complexes
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Phosphoproteins
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RPTOR protein, human
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Regulatory-Associated Protein of mTOR
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MTOR protein, human
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LRRK2 protein, human
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Mechanistic Target of Rapamycin Complex 1
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TOR Serine-Threonine Kinases
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Mitogen-Activated Protein Kinases