Tip110: Physical properties, primary structure, and biological functions

Life Sci. 2016 Mar 15:149:79-95. doi: 10.1016/j.lfs.2016.02.062. Epub 2016 Feb 16.

Abstract

HIV-1 Tat-interacting protein of 110kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110(nrb), was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.

Keywords: Development; Gene transcription; HIV replication; Post-translational modifications; Pre-mRNA splicing; Stem cell biology; Tip110.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Neoplasm / chemistry*
  • Antigens, Neoplasm / physiology*
  • Apoptosis / physiology
  • Humans
  • Molecular Sequence Data
  • Neurons / physiology
  • RNA Splicing / physiology
  • RNA, Messenger / physiology
  • RNA-Binding Proteins / chemistry*
  • RNA-Binding Proteins / physiology*

Substances

  • Antigens, Neoplasm
  • RNA, Messenger
  • RNA-Binding Proteins
  • SART3 protein, human