Bon EPOtit! S1P-Mediated EPO Signaling Whets a Macrophage's Appetite for Apoptotic Cells

Joseph P Kolb; Jennifer Martinez

doi:10.1016/j.immuni.2016.01.023

Bon EPOtit! S1P-Mediated EPO Signaling Whets a Macrophage's Appetite for Apoptotic Cells

Immunity. 2016 Feb 16;44(2):209-11. doi: 10.1016/j.immuni.2016.01.023.

Authors

Joseph P Kolb¹, Jennifer Martinez²

Affiliations

¹ Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.
² Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. Electronic address: jennifer.martinez3@nih.gov.

Abstract

Phagocytes clear dying cells within an organism to prevent damaging inflammation and autoimmunity. In this issue of Immunity, Luo et al. (2016) describe how "find-me" signals from apoptotic cells induce erythropoietin signaling within macrophages to prime them for efferocytosis.

Publication types

Comment

MeSH terms

Animals
Erythropoietin / metabolism*
Female
Lupus Erythematosus, Systemic / immunology*
Lysophospholipids / metabolism*
Macrophages / physiology*
Receptors, Erythropoietin / metabolism*
Sphingosine / analogs & derivatives*

Substances

Lysophospholipids
Receptors, Erythropoietin
Erythropoietin
Sphingosine

Abstract

Publication types

MeSH terms

Substances

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