Vitrified/warmed single blastocyst transfer in preimplantation genetic diagnosis/preimplantation genetic screening cycles

Jin Huang; Rong Li; Ying Lian; Lixue Chen; Xiaodan Shi; Jie Qiao; Ping Liu

Vitrified/warmed single blastocyst transfer in preimplantation genetic diagnosis/preimplantation genetic screening cycles

Int J Clin Exp Med. 2015 Nov 15;8(11):21605-10. eCollection 2015.

Authors

Jin Huang¹, Rong Li¹, Ying Lian¹, Lixue Chen², Xiaodan Shi², Jie Qiao¹, Ping Liu¹

Affiliations

¹ Department of Obstetrics and Gynecology, Reproductive Medical Centre, Peking University Third HospitalBeijing 100191, China; Key Laboratory of Assisted Reproduction, Ministry of Education and Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing 100191, China.
² Department of Obstetrics and Gynecology, Reproductive Medical Centre, Peking University Third Hospital Beijing 100191, China.

PMID: 26885112
PMCID: PMC4723957

Abstract

Objective: To investigate the single blastocyst transfer in preimplantation genetic diagnosis (PGD)/preimplantation genetic screening (PGS) cycles.

Methods: 80 PGD/PGS cycles undergoing blastocyst biopsy were studied. There were 88 warming cycles during the study period. Only one warmed blastocyst was transferred per cycle. The outcomes were followed up to the infants were born.

Results: The embryo implantation rate was 54.55% (48/88). The clinical pregnancy rate was 54.55% (48/88) per transfer cycle and 60% (48/80) per initial PGD/PGS cycle. There was no multi-pregnant in this study. The live birth rate was 42.05% (37/88) per transfer cycle and 46.25% (37/80) per initial PGD/PGS cycle.

Conclusion: In PGD/PGS cycles, single blastocyst transfer reduces the multiple pregnancy rate without affecting the clinical outcomes.

Keywords: Preimplantation genetic diagnosis/preimplantation genetic screening; multiple births; single blastocyst transfer; vitrification.