The risk of bradykinin B2 receptor-58T/C gene polymorphism on hypertension: a meta-analysis

Kaiping Luo; Wenling Kang; Gaosi Xu

The risk of bradykinin B2 receptor-58T/C gene polymorphism on hypertension: a meta-analysis

Int J Clin Exp Med. 2015 Nov 15;8(11):19917-27. eCollection 2015.

Authors

Kaiping Luo¹, Wenling Kang¹, Gaosi Xu²

Affiliations

¹ Medical Center of The Graduate School, Nanchang University China.
² Department of Nephrology, Second Affiliated Hospital, Nanchang University China.

PMID: 26884904
PMCID: PMC4723749

Abstract

Background: The risk of bradykinin B2 receptor (BDKRB2) -58T/C gene polymorphism on hypertension remains controversial.

Materials and methods: The Cochrane Library, Chinese Biomedical Database, EBSCO, Embase, ISI, MEDLINE, and PubMed were retrieved, and relevant articles were selected.

Results: The significant association between BDKRB2-58T/C gene polymorphism and risk of hypertension were found under C-allele comparison [odds ratio (OR): 1.22, 95% confidential intervals (CI): 1.05-1.42, recessive model (OR: 1.32, 95% CI: 1.07-1.64), dominant model (OR: 0.74, 95% CI: 0.58-0.94), homozygote model (OR: 1.66, 95% CI: 1.11-2.47) and heterozygote model (OR: 1.23, 95% CI: 1.06-1.43). The magnitude of the association between the BDKRB2-58T/C gene polymorphism and risk of hypertension was substantiated in Asians under C-allele comparison (OR: 1.24, 95% CI: 1.04-1.49), recessive model (OR: 1.39, 95% CI: 1.04-1.86), dominant model (OR: 0.72, 95% CI: 0.56-0.93), homozygote model (OR: 1.78, 95% CI: 1.09-2.90) and heterozygote model (OR: 1.26, 95% CI: 1.07-1.49). No publication bias was found in the meta-analysis.

Conclusions: The meta-analysis suggested -58C allele and -58CC genotype increase the risk of hypertension. Inversely, -58TT genotype decreases the risk of hypertension.

Keywords: Bradykinin B2 receptor; hypertension; meta-analysis; polymorphism.