CBr4 Mediated Oxidative C-N Bond Formation: Applied in the Synthesis of Imidazo[1,2-α]pyridines and Imidazo[1,2-α]pyrimidines

Congde Huo; Jing Tang; Haisheng Xie; Yajun Wang; Jie Dong

doi:10.1021/acs.orglett.6b00137

CBr4 Mediated Oxidative C-N Bond Formation: Applied in the Synthesis of Imidazo[1,2-α]pyridines and Imidazo[1,2-α]pyrimidines

Org Lett. 2016 Mar 4;18(5):1016-9. doi: 10.1021/acs.orglett.6b00137. Epub 2016 Feb 16.

Authors

Congde Huo¹, Jing Tang¹, Haisheng Xie¹, Yajun Wang¹, Jie Dong¹

Affiliation

¹ Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University , Lanzhou, Gansu 730070, China.

PMID: 26882001
DOI: 10.1021/acs.orglett.6b00137

Abstract

The carbon tetrabromide mediated oxidative carbon-nitrogen bond formation of 2-aminopyridines or 2-aminopyrimidines with β-keto esters or 1,3-diones, leading to a variety of complex imidazo[1,2-α]pyridines or imidazo[1,2-α]pyrimidines, is reported. The reactions were realized under mild and metal-free conditions.

Publication types

Research Support, Non-U.S. Gov't