Imaging synucleinopathies

David J Brooks; Nicola Tambasco

doi:10.1002/mds.26547

Imaging synucleinopathies

Mov Disord. 2016 Jun;31(6):814-29. doi: 10.1002/mds.26547. Epub 2016 Feb 16.

Authors

David J Brooks^{1

2

3}, Nicola Tambasco⁴

Affiliations

¹ Dept of Nuclear Medicine, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
² Dept of Medicine, Imperial College London, London, United Kingdom.
³ Division of Neurology, Newcastle University, Newcastle, United Kingdom.
⁴ Dept of Neurology, Azienda Ospedaliera e Universitaria di Perugia, Perugia, Italy.

PMID: 26879635
DOI: 10.1002/mds.26547

Abstract

In this review the structural and functional imaging changes associated with the synucleinopathies PD, MSA, and dementias associated with Lewy bodies are reviewed. The role of imaging for supporting differential diagnosis, detecting subclinical disease, and following disease progression is discussed and its potential use for monitoring disease progression is debated. © 2016 International Parkinson and Movement Disorder Society.

Keywords: DLB; MRI; MSA; PET; Parkinson's; SPECT.

Publication types

Review

MeSH terms

Humans
Lewy Body Disease* / diagnostic imaging
Lewy Body Disease* / metabolism
Lewy Body Disease* / pathology
Multiple System Atrophy* / diagnostic imaging
Multiple System Atrophy* / metabolism
Multiple System Atrophy* / pathology
Parkinson Disease* / diagnostic imaging
Parkinson Disease* / metabolism
Parkinson Disease* / pathology
Substantia Nigra* / diagnostic imaging
Substantia Nigra* / metabolism
Substantia Nigra* / pathology
alpha-Synuclein / metabolism*

Substances

alpha-Synuclein