Implantation of Modular Photovoltaic Subretinal Prosthesis

Ophthalmic Surg Lasers Imaging Retina. 2016 Feb;47(2):171-4. doi: 10.3928/23258160-20160126-11.

Abstract

Background and objective: Establish the surgical procedure for subretinal implantation of multiple photovoltaic arrays for the restoration of sight.

Materials and methods: Multiple silicon photovoltaic arrays of 1 mm in diameter and 30 µm in thickness were implanted subretinally via single retinotomy in rabbits. Ophthalmoscopic imaging and optical coherence tomography (OCT) were used to validate the implants' placement.

Results: Vitrectomy, followed by subretinal fluid injection for retinal detachment and retinotomy, allowed accurate placement of seven modules in the bleb, covering approximately a 3.5-mm diameter area on the retina via a single 1.5-mm retinotomy. OCT confirmed complete reattachment of the retina over the implants.

Conclusion: Subretinal implantation of multiple photovoltaic arrays via a single retinotomy, followed by their tiling, minimizes the scleral and retinal incisions and provides better fit to the spherical shape of the eye ball, compared to a single, larger module. Such minimally traumatic procedure can be performed with 20-gauge intraocular instruments.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Electric Stimulation Therapy / instrumentation*
  • Electrodes, Implanted*
  • Microelectrodes
  • Prosthesis Implantation / methods*
  • Rabbits
  • Retina / pathology
  • Retina / surgery*
  • Retinal Detachment / pathology
  • Retinal Detachment / surgery
  • Tomography, Optical Coherence
  • Visual Prosthesis*
  • Vitrectomy