A Receptor for All Occasions

Darrell J Irvine

doi:10.1016/j.cell.2016.01.030

A Receptor for All Occasions

Cell. 2016 Feb 11;164(4):599-600. doi: 10.1016/j.cell.2016.01.030.

Author

Darrell J Irvine¹

Affiliation

¹ David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Department of Materials Science & Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; The Ragon Institute of MGH, Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, Massachusetts 02139, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA. Electronic address: djirvine@mit.edu.

PMID: 26871625
DOI: 10.1016/j.cell.2016.01.030

Abstract

Cells communicate with their environment, in part, through cell surface receptors. Engineering receptors that both sense arbitrary inputs and provide outputs orthogonal to endogenous signaling pathways has been a challenge. Now, Lim and colleagues report a system based on synthetic Notch receptors that allows independent control of both inputs and outputs in diverse cell types.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Cell Engineering*
Humans
Immunotherapy / methods*
Neoplasms / immunology*
Neoplasms / therapy*
Receptors, Notch / chemistry*
Signal Transduction*
Synthetic Biology / methods*
T-Lymphocytes / metabolism*

Substances

Receptors, Notch

Grants and funding

Howard Hughes Medical Institute/United States