Objective: To investigate the clinicopathological characteristics, prognosis and the pregnancy condition after preserving fertility function surgery of borderline ovarian tumors with intraepithelial carcinoma (OIC).
Methods: Clinical data of 29 patients with OIC at Department of Gynecology, West China Second University Hospital, Sichuan University, between January 2005 and March 2014, were collected for retrospectively analysis with 6-93 months follow-up. The recurrence rate and pregnancy rate after preserving fertility function surgery were compared.
Results: OIC patients accounts for 4.0% (29/719) in borderline tumors patients, including fertility preserving function requirement 51.7% (15/29). All patients underwent surgery treatment, including conservative surgery 51.7% (15/29), radical surgery 48.3% (14/29). Adjuvant chemotherapy 27.6% (8/29). Pathological types: mucinous 69.0% (20/29), serous 13.8% (4/29), endometrioid 6.9% (2/29) and mixed 10.3% (3/29). FIGO stage: I a 75.9% (22/29), I b 17.2% (5/29), I c 6.9% (2/29). The average follow-up time was 49.6 months, the recurrence rate was 10.3% (3/29), the pregnancy rate was 66.7% (10/15). The recurrence rate of higher stage and intraoperative retaining ovaries was higher (P = 0.005, P = 0.005); the pregnancy rate of younger patients was higher (P=0.017).
Conclusion: OIC patients are young, diagnosed at an early stage. Pathological types are mainly mucinous. For patients with fertility requirements, the recurrence rate of ovarian tumor excision surgery is very high.