CRISPR-Cas Gatekeeper: Slow on the Uptake but Gets the Job Done

Rachel J Whitaker; Carin K Vanderpool

doi:10.1016/j.chom.2016.01.015

CRISPR-Cas Gatekeeper: Slow on the Uptake but Gets the Job Done

Cell Host Microbe. 2016 Feb 10;19(2):135-7. doi: 10.1016/j.chom.2016.01.015.

Authors

Rachel J Whitaker¹, Carin K Vanderpool²

Affiliations

¹ Department of Microbiology, University of Illinois at Urbana-Champaign. Electronic address: rwhitaker@life.illinois.edu.
² Department of Microbiology, University of Illinois at Urbana-Champaign.

PMID: 26867170
DOI: 10.1016/j.chom.2016.01.015

Abstract

Microbial CRISPR-Cas acts as a defense, but also as a gatekeeper controlling the flow of new genes into microbial genomes. In a recent Cell paper, Jiang et al. (2016) uncover the functional importance of transcription-dependent RNA targeting in type III-A CRISPR-Cas antiviral defense and provide insight into the co-evolution of virus-host symbioses.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

CRISPR-Cas Systems*
RNA Stability*
Staphylococcus Phages / genetics*
Staphylococcus epidermidis / immunology*

Grants and funding

GM092830/GM/NIGMS NIH HHS/United States