Microbes without Borders: Decompartmentalization of the Aging Gut

Erin S Keebaugh; William W Ja

doi:10.1016/j.chom.2016.01.016

Microbes without Borders: Decompartmentalization of the Aging Gut

Cell Host Microbe. 2016 Feb 10;19(2):133-5. doi: 10.1016/j.chom.2016.01.016.

Authors

Erin S Keebaugh¹, William W Ja²

Affiliations

¹ Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.
² Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: wja@scripps.edu.

PMID: 26867169
DOI: 10.1016/j.chom.2016.01.016

Abstract

The microbiota supports intestinal homeostasis in developing animals. With increased age, gut maintenance declines and microbes can stray from traditional zones, negatively impacting host health. In this issue of Cell Host & Microbe, Li et al. (2016) detail the mechanisms leading to the decline in intestinal health in aged flies.

Publication types

Comment

MeSH terms

Aging
Animals
Gastrointestinal Tract*
Homeostasis
Humans
Intestines
Microbiota*