[Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice]

S Ya Loginova; S V Borisevich; V L Rusinov; E N Ulomsky; V N Charushin; O N Chupakhin; P V Sorokin

[Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice]

Antibiot Khimioter. 2015;60(7-8):11-3.

[Article in Russian]

Authors

S Ya Loginova, S V Borisevich, V L Rusinov, E N Ulomsky, V N Charushin, O N Chupakhin, P V Sorokin

PMID: 26863736

Abstract

The comparative study of the therapeutic efficacy of Triazavirin against experimental Forest-Spring encephalitis on albino mice vs. the active drug Ribavirin® showed that in high doses (200-400 mg/kg) Triazavirin moderately protected the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically (p ≤ 0.05) valid decrease of the virus accumulation in the target organ (the brain) were observed.

Publication types

Comparative Study

MeSH terms

Animals
Antiviral Agents / pharmacology*
Azoles / pharmacology*
Brain / drug effects
Brain / pathology
Brain / virology
Encephalitis Viruses, Tick-Borne / drug effects*
Encephalitis Viruses, Tick-Borne / pathogenicity
Encephalitis Viruses, Tick-Borne / physiology
Encephalitis, Tick-Borne / drug therapy*
Encephalitis, Tick-Borne / mortality
Encephalitis, Tick-Borne / pathology
Encephalitis, Tick-Borne / virology
Mice
Ribavirin / pharmacology
Survival Analysis
Treatment Outcome
Triazines / pharmacology*
Triazoles
Viral Load / drug effects
Virus Replication / drug effects*

Substances

Antiviral Agents
Azoles
Triazines
Triazoles
Ribavirin
riamilovir