ER Stress and β-Cell Pathogenesis of Type 1 and Type 2 Diabetes and Islet Transplantation

Hitomi Usui Kataoka; Hirofumi Noguchi

doi:10.3727/215517913X666512

ER Stress and β-Cell Pathogenesis of Type 1 and Type 2 Diabetes and Islet Transplantation

Cell Med. 2013 May 14;5(2-3):53-7. doi: 10.3727/215517913X666512. eCollection 2013 Nov 10.

Authors

Hitomi Usui Kataoka¹, Hirofumi Noguchi²

Affiliations

¹ Department of Primary Care and Medical Education, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
² † Department of Surgery, Clinical Research Center, Chiba-East Hospital, National Hospital Organization , Chiba , Japan.

Abstract

Endoplasmic reticulum (ER) stress affects the pathogenesis of diabetes. ER stress plays important roles, both in type 1 and type 2 diabetes, because pancreatic β-cells possess highly developed ER for insulin secretion. This review summarizes the relationship between ER stress and the pathogenesis of type 1 and type 2 diabetes. In addition, the association between islet transplantation and ER stress is discussed.

Keywords: Endoplasmic reticulum (ER) stress; Islet transplantation; β-Cells.

Publication types

Review