Lung Transplantation for Cystic Fibrosis

Matthew R Morrell; Joseph M Pilewski

doi:10.1016/j.ccm.2015.11.008

Lung Transplantation for Cystic Fibrosis

Clin Chest Med. 2016 Mar;37(1):127-38. doi: 10.1016/j.ccm.2015.11.008.

Authors

Matthew R Morrell¹, Joseph M Pilewski²

Affiliations

¹ Lung Transplant Program, University of Pittsburgh Medical Center, NW628 MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA.
² Lung Transplant Program, University of Pittsburgh Medical Center, NW628 MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA; Adult Cystic Fibrosis Program, Children's Hospital of Pittsburgh of UPMC and University of Pittsburgh Medical Center, NW628 MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA. Electronic address: pilewskijm@upmc.edu.

PMID: 26857774
DOI: 10.1016/j.ccm.2015.11.008

Abstract

Lung transplantation is a viable option for many patients with cystic fibrosis (CF) and end-stage lung disease. Criteria for transplant in patients with CF vary widely among transplant centers in terms of acceptable comorbidities; referral to multiple centers may be necessary to maximize patient opportunity for this potentially life-prolonging intervention. Early referral is critical to patient education and modification of risk factors associated with worse outcomes. If transplant evaluation has been completed, patients with CF and respiratory failure requiring mechanical ventilation and extracorporeal membrane oxygenation may remain viable candidates for transplant with outcomes comparable to other individuals with CF.

Keywords: Advanced lung disease; Burkholderia cepacia; Cystic fibrosis; Lung transplantation; Nontuberculous mycobacteria; Respiratory failure.

Publication types

Review

MeSH terms

Cystic Fibrosis / complications
Cystic Fibrosis / surgery*
Humans
Life Support Care / methods*
Lung Transplantation / methods*
Referral and Consultation
Respiratory Insufficiency / etiology*
Respiratory Insufficiency / surgery
Risk Factors