The Microbiome in Cystic Fibrosis

Yvonne J Huang; John J LiPuma

doi:10.1016/j.ccm.2015.10.003

The Microbiome in Cystic Fibrosis

Clin Chest Med. 2016 Mar;37(1):59-67. doi: 10.1016/j.ccm.2015.10.003. Epub 2015 Dec 23.

Authors

Yvonne J Huang¹, John J LiPuma²

Affiliations

¹ Division of Pulmonary/Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III/SPC 5642, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: yvjhuang@umich.edu.
² Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, 8323 MSRB III/SPC 5646, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA.

Abstract

Observations from studies during the last decade have changed the conventional view of cystic fibrosis (CF) microbiology, which has traditionally focused on a limited suite of opportunistic bacterial pathogens. It is now appreciated that CF airways typically harbor complex microbial communities, and that changes in the structure and activity of these communities have a bearing on patient clinical condition and lung disease progression. Recent studies of gut microbiota also suggest that disordered bacterial ecology of the CF gastrointestinal tract is associated with pulmonary outcomes. These new insights may alter future clinical management of CF.

Keywords: Bacteria; Culture-independent; Fungi; Gut; Lung; Microbiota; Virus.

Publication types

Review

MeSH terms

Bacterial Infections / complications*
Bacterial Infections / microbiology
Cystic Fibrosis / complications*
Cystic Fibrosis / microbiology
Humans
Lung / microbiology*
Microbiota*

Grants and funding

K23 HL105572/HL/NHLBI NIH HHS/United States