Pruning Cancer's Evolutionary Tree with Lesion-Directed Therapy

Crispin T Hiley; Charles Swanton

doi:10.1158/2159-8290.CD-15-1493

Pruning Cancer's Evolutionary Tree with Lesion-Directed Therapy

Cancer Discov. 2016 Feb;6(2):122-4. doi: 10.1158/2159-8290.CD-15-1493.

Authors

Crispin T Hiley¹, Charles Swanton²

Affiliations

¹ University College London Cancer Institute and The Francis Crick Institute, London, United Kingdom.
² University College London Cancer Institute and The Francis Crick Institute, London, United Kingdom. charles.swanton@crick.ac.uk.

Abstract

Next-generation sequencing of spatially and temporally separated biopsies and circulating tumor DNA directs therapy in response to tumor evolution and acquired resistance in colorectal cancer.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Colorectal Neoplasms*
DNA, Neoplasm / genetics*
High-Throughput Nucleotide Sequencing
Humans

Substances

DNA, Neoplasm

Abstract

Publication types

MeSH terms

Substances

Grants and funding