Non-alkaloid constituents of Vinca major

Chin J Nat Med. 2016 Jan;14(1):56-60. doi: 10.3724/SP.J.1009.2016.00056.

Abstract

The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination with UV, IR, and MS analyses. The 1, 1-diphenyl-2-picrylhydrazyl (DPPH)-scavenging activity of Compounds 1-7 were evaluated. One new iridoid glycoside (compound 1), together with 11 known compounds, were isolated from Vinca major. Compounds 1, 5, and 6 showed moderate DPPH-scavenging activity, with IC50 values being 70.6, 32.8, and 62.2 μmol·L(-1), respectively. In conclusion, compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity.

Keywords: Antioxidant; Iridoid glycoside; Vinca major; Vinmaside A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / pharmacology
  • Iridoid Glycosides / chemistry
  • Iridoid Glycosides / isolation & purification*
  • Iridoid Glycosides / pharmacology
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Vinca / chemistry*

Substances

  • Antioxidants
  • Iridoid Glycosides