Experimental replacement of esophagus with a short segment of trachea

Azizollah Abbasidezfouli; Damoon Ansari; Kambiz Sheikhy; Mohammad Abarkar; Farahnaz Sadeghbeigi; Sepehr Abbasidezfouli; Davood Sharifi

doi:10.1016/j.jss.2015.10.017

Experimental replacement of esophagus with a short segment of trachea

J Surg Res. 2016 Mar;201(1):94-8. doi: 10.1016/j.jss.2015.10.017. Epub 2015 Oct 23.

Authors

Azizollah Abbasidezfouli¹, Damoon Ansari², Kambiz Sheikhy³, Mohammad Abarkar⁴, Farahnaz Sadeghbeigi¹, Sepehr Abbasidezfouli⁵, Davood Sharifi⁶

Affiliations

¹ Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: ksheikhy@sbmu.ac.ir.
⁴ Faculty of Veterinary Medicine, Karaj branch of Islamic Azad University, Karaj, Iran.
⁵ Telemedicine Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Department of Clinical Science, Surgery and Radiology Section, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

PMID: 26850189
DOI: 10.1016/j.jss.2015.10.017

Abstract

Background: Segmental resection of esophagus with primary anastomosis is prohibited because of the risk of dehiscence. We previously have shown that replacement of a segment of cervical esophagus with a tracheal segment of the same length could successfully be performed in a canine model. In this study, we sought to assess the feasibility of replacement of the esophageal defect with a shorter segment of trachea.

Methods: In five mongrel dogs weighting 20-30 kg, under general anesthesia and after a cervical incision, 8 cm of the cervical esophagus was resected and replaced by a 4-cm segment of the adjacent trachea. The animals were evaluated clinically for signs and symptoms of stenosis and dehiscence and then euthanized after 2 mo of follow-up.

Results: All dogs recovered from surgery and started regular diet on the seventh postoperative day. No clinical or endoscopic sign of stenosis or voice change was seen. Squamous metaplasia and atrophy of mucosal glands and cartilage were detected in the histopathologic examination of the replaced segments.

Conclusions: Replacement of a cervical esophageal defect with a shorter segment of trachea can be performed successfully in dogs. This procedure can be potentially used for the treatment of cervical esophageal lesions in humans.

Keywords: Anastomosis; Esophagus; Replacement; Resection; Trachea.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dogs
Esophagectomy*
Trachea / transplantation*