A porous metal-organic framework with a unique hendecahedron-shaped cage: structure and controlled drug release

Dalton Trans. 2016 Mar 7;45(9):3694-7. doi: 10.1039/c5dt04379d.

Abstract

A porous MOF constructed from a [Cu2(COO)4] secondary building unit, H3L (H3L = [1,1';3',1'']terphenyl-4,5',4''-tricarboxylic acid), and pyrazine ligands features a unique hendecahedron cage-like cavity with good stability and a high BET surface area of 3235 m(2) g(-1), showing good controlled drug release property of ibuprofen over those of anethole and guaiacol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carboxylic Acids / chemistry
  • Copper / chemistry
  • Delayed-Action Preparations
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Ibuprofen / chemistry
  • Ligands
  • Models, Molecular
  • Molecular Conformation
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry*
  • Porosity
  • Pyrazines / chemistry

Substances

  • Carboxylic Acids
  • Delayed-Action Preparations
  • Drug Carriers
  • Ligands
  • Organometallic Compounds
  • Pyrazines
  • pyrazine-2-carboxylate
  • Copper
  • Ibuprofen