Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives

Hugh S O'Neill; Laura B Gallagher; Janice O'Sullivan; William Whyte; Clive Curley; Eimear Dolan; Aamir Hameed; Joanne O'Dwyer; Christina Payne; Daniel O'Reilly; Eduardo Ruiz-Hernandez; Ellen T Roche; Fergal J O'Brien; Sally Ann Cryan; Helena Kelly; Bruce Murphy; Garry P Duffy

doi:10.1002/adma.201505349

Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives

Adv Mater. 2016 Jul;28(27):5648-61. doi: 10.1002/adma.201505349. Epub 2016 Feb 3.

Authors

Hugh S O'Neill^{1

2}, Laura B Gallagher^{1

2}, Janice O'Sullivan^{1

2}, William Whyte^{1

3}, Clive Curley^{1

2}, Eimear Dolan^{1

2}, Aamir Hameed^{1

2}, Joanne O'Dwyer^{1

2

4}, Christina Payne^{1

4}, Daniel O'Reilly¹, Eduardo Ruiz-Hernandez^{1

2

3}, Ellen T Roche⁵, Fergal J O'Brien^{1

3}, Sally Ann Cryan^{1

2

4}, Helena Kelly^{1

4}, Bruce Murphy^{2

3}, Garry P Duffy^{1

2

3}

Affiliations

¹ Tissue Engineering Research Group (TERG), Department of Anatomy, Royal College of Surgeons in Ireland (RSCI), 123, St. Stephens Green, Dublin 2, Dublin, D02 YN77, Ireland.
² Trinity Center for Bioengineering (TCBE), Trinity College Dublin, Dublin 2, Dublin, Ireland.
³ Advanced Materials and Bioengineering Research Center (AMBER), RCSI and TCD, Dublin, Ireland.
⁴ School of Pharmacy, Royal College of Surgeons in Ireland, 123, St. Stephens Green, Dublin 2, Dublin, Ireland.
⁵ Department of Biomedical Engineering, Eng-2053, Engineering Building, National University of Ireland, Galway, Ireland.

PMID: 26840955
DOI: 10.1002/adma.201505349

Abstract

Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardiac tissue engineering with a focus on advanced delivery strategies and the use of multimodal therapeutic strategies are reviewed.

Keywords: biomaterials; cardiac tissue engineering; drug delivery; hydrogels; stem cell therapy.

Publication types

Review

MeSH terms

Biocompatible Materials
Drug Delivery Systems
Heart*
Tissue Engineering
Tissue Scaffolds

Substances

Biocompatible Materials