Diarrheal Illness in the Pediatric Population: A Review of Neonatal Enteropathies and Childhood Idiopathic Inflammatory Bowel Disease

Eric U Yee; Jeffrey D Goldsmith

doi:10.1016/j.path.2013.05.006

Diarrheal Illness in the Pediatric Population: A Review of Neonatal Enteropathies and Childhood Idiopathic Inflammatory Bowel Disease

Surg Pathol Clin. 2013 Sep;6(3):523-43. doi: 10.1016/j.path.2013.05.006. Epub 2013 Aug 6.

Authors

Eric U Yee¹, Jeffrey D Goldsmith²

Affiliations

¹ Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Children's Hospital Boston, 330 Brookline Avenue, Boston, MA 02215, USA.
² Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Children's Hospital Boston, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address: jgoldsmi@bidmc.harvard.edu.

PMID: 26839099
DOI: 10.1016/j.path.2013.05.006

Abstract

In the clinical context of pediatric diarrheal illness, the interpretation of endoscopic mucosal biopsies varies significantly from that in adults. This review outlines these differences by first describing a host of diarrheal illnesses that are nearly exclusive to the pediatric age group. The final portion of this article describes salient pathologic differences between adult and pediatric idiopathic inflammatory bowel disease. The goal of this review is to provide a brief description of each disease process and focus on practical aspects of diagnosis that are applicable for pathologists working in general practice settings.

Keywords: Autoimmune enteropathy; Chronic granulomatous disease; Enteroendocrine cell dysgenesis; Hypobetalipoproteinemias; Immunodeficiencies; Microvillous inclusion disease; Tufting enteropathy.