Hydroxypropyl-β-cyclodextrin-graphene oxide conjugates: Carriers for anti-cancer drugs

Jingting Tan; Na Meng; Yunting Fan; Yutian Su; Ming Zhang; Yinghong Xiao; Ninglin Zhou

doi:10.1016/j.msec.2015.12.098

Hydroxypropyl-β-cyclodextrin-graphene oxide conjugates: Carriers for anti-cancer drugs

Mater Sci Eng C Mater Biol Appl. 2016 Apr 1:61:681-7. doi: 10.1016/j.msec.2015.12.098. Epub 2016 Jan 5.

Authors

Jingting Tan¹, Na Meng¹, Yunting Fan¹, Yutian Su¹, Ming Zhang¹, Yinghong Xiao², Ninglin Zhou³

Affiliations

¹ Jiangsu Collaborative Innovation Center for Biological Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing 210023, China; Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing 210023, China.
² Jiangsu Collaborative Innovation Center for Biological Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing 210023, China; Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing 210023, China. Electronic address: yhxiao@njnu.edu.cn.
³ Jiangsu Collaborative Innovation Center for Biological Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing 210023, China; Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing 210023, China; Nanjing Zhou Ninglin Advanced Materials Technology Company Limited, Nanjing 211505, China. Electronic address: zhouninglin@njnu.edu.cn.

PMID: 26838897
DOI: 10.1016/j.msec.2015.12.098

Abstract

A novel drug carrier based on hydroxypropyl-β-cyclodextrin (HP-β-CD) modified carboxylated graphene oxide (GO-COOH) was designed to incorporate anti-cancer drug paclitaxel (PTX). The formulated nanomedicines were characterized by Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM). Results showed that PTX can be incorporated into GO-COO-HP-β-CD nanospheres successfully, with an average diameter of about 100 nm. The solubility and stability of PTX-loaded GO-COO-HP-β-CD nanospheres in aqueous media were greatly enhanced compared with the untreated PTX. The results of hemolysis test demonstrated that the drug-loaded nanospheres were qualified with good blood compatibility for intravenous use. In vitro anti-tumor activity was measured and results demonstrated that the incorporation of PTX into the newly developed GO-COO-HP-β-CD carrier could confer significantly improved cytotoxicity to the nanosystem against tumor cells than single application of PTX. GO-COO-HP-β-CD nanospheres may represent a promising formulation platform for a broad range of therapeutic agent, especially those with poor solubility.

Keywords: Blood compatibility; Graphene oxide; Hydroxypropyl-beta-cyclodextrin; Paclitaxel.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2-Hydroxypropyl-beta-cyclodextrin
Animals
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / toxicity
Cell Survival / drug effects
Drug Carriers / chemistry*
Drug Carriers / toxicity
Erythrocytes / cytology
Erythrocytes / drug effects
Graphite / chemistry*
Hemolysis / drug effects
Humans
Hydrogen-Ion Concentration
Microscopy, Atomic Force
Oxides / chemistry
Paclitaxel / chemistry*
Paclitaxel / toxicity
Solubility
Spectroscopy, Fourier Transform Infrared
beta-Cyclodextrins / chemistry*

Substances

Antineoplastic Agents, Phytogenic
Drug Carriers
Oxides
beta-Cyclodextrins
2-Hydroxypropyl-beta-cyclodextrin
Graphite
Paclitaxel