Molecular Pathology of the Genitourinary Tract: Molecular Pathology of Kidney and Testes

S Joseph Sirintrapun; Anil V Parwani

doi:10.1016/j.path.2008.08.003

Molecular Pathology of the Genitourinary Tract: Molecular Pathology of Kidney and Testes

Surg Pathol Clin. 2009 Mar;2(1):199-223. doi: 10.1016/j.path.2008.08.003. Epub 2009 Jan 27.

Authors

S Joseph Sirintrapun¹, Anil V Parwani²

Affiliations

¹ Pathology Informatics, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.
² Department of Pathology, University of Pittsburgh Medical Center Shadyside Hospital, Room WG 07, 5230 Centre Avenue, Pittsburgh, PA 15232, USA. Electronic address: parwaniav@upmc.edu.

PMID: 26838102
DOI: 10.1016/j.path.2008.08.003

Abstract

With the advent of newer molecular technologies, our knowledge of cellular mechanisms with tumors of the kidney and testis has grown exponentially. Molecular technologies have led to better understanding of interplay between the von Hippel-Lindau gene and angiogenic cytokines in renal cancer and isochromosome 12p in testicular neoplasms. The result has been development of antiangiogenic-targeted therapy within recent years that has become the mainstay treatment for metastatic renal cell cancer. In the near future, classification and diagnosis of renal and testicular tumors through morphologic analysis will be supplemented by molecular information correlating to prognosis and targeted therapy. This article outlines tumor molecular pathology of the kidney and testis encompassing current genomic, epigenomic, and proteonomic findings.

Keywords: Molecular pathology; Renal neoplasms; Testicular tumors.

Publication types

Review