Implications of endogenous roles of transporters for drug discovery: hitchhiking and metabolite-likeness

Nat Rev Drug Discov. 2016 Feb;15(2):143. doi: 10.1038/nrd.2015.44.

Author

Douglas B Kell¹

Affiliation

¹ School of Chemistry, The Manchester Institute of Biotechnology, and the Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

PMID: 26837595
DOI: 10.1038/nrd.2015.44

No abstract available

Publication types

Letter

MeSH terms

Animals
Drug Discovery / methods
Drug Discovery / trends*
Humans
Membrane Transport Proteins / metabolism*
Pharmaceutical Preparations / administration & dosage
Pharmaceutical Preparations / metabolism*

Substances

Membrane Transport Proteins
Pharmaceutical Preparations