Non-neoplastic Pathology in Tumor Nephrectomy Specimens

Vanesa Bijol; Ibrahim Batal

doi:10.1016/j.path.2014.04.001

Non-neoplastic Pathology in Tumor Nephrectomy Specimens

Surg Pathol Clin. 2014 Sep;7(3):291-305. doi: 10.1016/j.path.2014.04.001. Epub 2014 Jun 26.

Authors

Vanesa Bijol¹, Ibrahim Batal²

Affiliations

¹ Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: VBijol@partners.org.
² Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

PMID: 26837441
DOI: 10.1016/j.path.2014.04.001

Abstract

Risk factors for kidney cancers and medical kidney diseases are similar; therefore, it is not surprising that up to 25% of renal cell carcinoma patients have chronic kidney disease prior to nephrectomy and a significant number of patients with normal prenephrectomy renal function markers progress to chronic kidney disease over time. Evaluation of non-neoplastic parenchyma in tumor nephrectomy specimens can identify patients at risk for progression to chronic kidney disease, which is a critical step for early intervention and potential improvement of morbidity and mortality rates in this patient population.

Keywords: Diabetic glomerulosclerosis; Nephrectomy; Normal kidney; Renal tumor; Solitary kidney; Vascular sclerosis.

Publication types

Review