Dietary folate, one-carbon metabolism-related genes, and gastric cancer risk in Korea

Mol Nutr Food Res. 2016 Feb;60(2):337-45. doi: 10.1002/mnfr.201500384. Epub 2015 Nov 17.

Abstract

Scope: We evaluated the interactions between polymorphisms involved in one-carbon metabolism-related genes and dietary folate intake in gastric cancer risk within the Korean population through a hospital-based case-control study.

Methods and results: A total of 542 controls and 271 cases were included. Genotype data were selected from data produced by the Affymetrix Axiom(®) Exome 319 Array. We considered seven single nucleotide polymorphisms (SNPs) of five genes whose SNPs are located in the coding region with a minor allele frequency > 5%: MTHFR (G1793A, A1298C, C677T), MTR A2756G, MTRR A66G, SHMT1 C1420T, and SLC19A1 G80A. Our study found that MTR A2756G was associated with a decreased gastric cancer risk. MTHFR G1793A showed a statistically significant interaction between dietary folate intake and gastric cancer.

Conclusion: Our results suggest that MTR A2756G is significantly associated with gastric cancer risk, and that MTHFR G1793A statistically interacts with dietary folate intake. Our findings indicate that gene-folate interactions may contribute to gastric cancer risk.

Keywords: Effect modification; Folate; Gastric cancer; Interaction; One-carbon metabolism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / genetics*
  • Asian People / genetics
  • Carbon / metabolism*
  • Case-Control Studies
  • Diet
  • Female
  • Ferredoxin-NADP Reductase / genetics
  • Folic Acid / pharmacology*
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Glycine Hydroxymethyltransferase / genetics
  • Humans
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Reduced Folate Carrier Protein / genetics
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / prevention & control

Substances

  • Reduced Folate Carrier Protein
  • SLC19A1 protein, human
  • Carbon
  • Folic Acid
  • methionine synthase reductase
  • Ferredoxin-NADP Reductase
  • MTHFR protein, human
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
  • MTR protein, human
  • Glycine Hydroxymethyltransferase
  • SHMT protein, human