[Dichloroacetate--a healing toxin or a toxic drug?]

Przegl Lek. 2015;72(9):479-81.
[Article in Polish]

Abstract

Dichloroacetate (DCA) is a compound which activity is observed by experimental and clinical toxicologists. DCA is a by-product of chlorination of water, it is toxic to many organs, such as liver, kidneys or nervous system. In a view of its metabolism it is also demonstrated that this substance may be treated as a drug in various medical conditions, such as different types of tumors for example.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Brain / drug effects
  • Carcinogens / toxicity
  • Dichloroacetic Acid / therapeutic use*
  • Dichloroacetic Acid / toxicity*
  • Humans
  • Hypertension, Pulmonary / drug therapy
  • Liver / drug effects
  • Mitochondria / drug effects
  • Neoplasms / drug therapy
  • Neoplasms / etiology

Substances

  • Antineoplastic Agents
  • Carcinogens
  • Dichloroacetic Acid