Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

Z Zhang; B Schepens; L Nuhn; X Saelens; M Schotsaert; N Callewaert; R De Rycke; Q Zhang; S Moins; S Benali; L Mespouille; R Hoogenboom; B G De Geest

doi:10.1039/c6cc00501b

Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

Chem Commun (Camb). 2016 Feb 25;52(16):3352-5. doi: 10.1039/c6cc00501b.

Authors

Z Zhang¹, B Schepens², L Nuhn¹, X Saelens², M Schotsaert², N Callewaert², R De Rycke², Q Zhang³, S Moins⁴, S Benali⁴, L Mespouille⁴, R Hoogenboom³, B G De Geest¹

Affiliations

¹ Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. br.degeest@ugent.be.
² Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, 9052 Zwijnaarde, Belgium and Inflammation Research Center, VIB, Technologiepark 927, 9052 Zwijnaarde, Belgium.
³ Supramolecular Chemistry Group, Department of Organic and Macromolecular Chemistry, Krijgslaan 281, 9000 Ghent, Belgium.
⁴ Laboratory of Polymeric & Composite Materials, Ctr Innovat & Res Mat & Polymers (CIRMAP), Material Res Inst. and Health Res. Inst., University of Mons, B-7000 Mons, Belgium.

PMID: 26823186
DOI: 10.1039/c6cc00501b

Abstract

We report on a straightforward strategy to fabricate bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol-gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-α-2-6-Gal, and we demonstrate multivalent and specific recognition between the nanoparticles, lectins and hemagglutinin on the surface of the influenza virus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Gold / chemistry*
Metal Nanoparticles / chemistry*
Oxidation-Reduction
Polymerization
Polymers / chemistry*

Substances

Polymers
Gold