Objective: To evaluate the correlation between chromosomal polymorphisms and male sperm quality in Jilin Province.
Methods: A total of 2 584 male patients with infertility in Center for Reproductive Medicine, First Bethune Hospital of Jilin University from 2008 to 2013 were enrolled, which semen analysis, chromosomal analysis, Y chromosome microdeletion analysis and serum hormone levels analysis were performed. A total of 602 healthy individuals, 50 fertile individuals with normal kayrotypes, 50 azoospermia patients with normal kayrotypes and 50 oligospermia patients with normal kayrotypes were selected as control groups.
Results: There was no significant difference in the frequency of chromosome polymorphisms between infertile patients and normal control individuals (3.91% (101/2 584) vs 3.16% (19/602), P > 0.05). And there was no significant difference in the frequency of autosomal polymorphisms between infertile patients and normal control individuals (all P > 0.05). The frequency of Yqh-variant was increased by the decrease of sperm count and it appeared a significantly high frequency in azoospermia patients compared with oligospermia patients and sperm count normal patients in the infertile group (57.14% (21/42) vs 24.32% (9/37), 0 (0/13), both P < 0.05). There was no significant difference in the testis volume and serum hormone levels between the infertile patients with chromosomal polymorphisms and patients in control groups with normal kayrotypes (all P > 0.05). The results of PCR amplication indicated that 32.14% (9/28) patients with Yqh ± had Y chromosome microdeletion.
Conclusions: There is no significant correlation between autosomal polymorphisms and male infertility. But Yqh ± may be responsible for Y chromosome microdeletion and male infertility.