Development of Food-Grade Curcumin Nanoemulsion and its Potential Application to Food Beverage System: Antioxidant Property and In Vitro Digestion

J Food Sci. 2016 Mar;81(3):N745-53. doi: 10.1111/1750-3841.13224. Epub 2016 Jan 25.

Abstract

Curcumin nanoemulsions (Cur-NEs) were developed with various surfactant concentrations by using high pressure homogenization and finally applied to the commercial milk system. Characterization of Cur-NEs was performed by measuring the droplet size and polydispersity index value at different Tween 20 concentrations. The morphology of the Cur-NEs was observed by confocal laser scanning microscopy and transmission electron microscopy. Antioxidant activity and in vitro digestion ability were tested using 2,2-diphenyl-1-picrylhydrazyl, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, pH-stat method, and thiobarbituric acid reactive substances assays. Cur-NEs were found to be physically stable for 1 mo at room temperature. The surfactant concentration affects particle formation and droplet size. The mean droplet size decreased from 122 to 90 nm when surfactant concentration increased 3 times. Cur-NEs had shown an effective oxygen scavenging activity. Cur-NEs-fortified milk showed significantly lower lipid oxidation than control (unfortified) milk and milk containing curcumin-free nanoemulsions. These properties make Cur-NEs suitable systems for the beverage industry.

Keywords: antioxidants; curcumin, in vitro digestion; curcumin-fortified milk; nanoemulsions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemistry*
  • Antioxidants / pharmacology
  • Biological Availability
  • Biphenyl Compounds / metabolism
  • Curcuma / chemistry*
  • Curcumin / chemistry*
  • Curcumin / pharmacology
  • Diet
  • Digestion
  • Emulsions / chemistry*
  • Food Handling / methods*
  • Humans
  • In Vitro Techniques
  • Lipid Peroxidation / drug effects*
  • Milk / chemistry*
  • Oxidation-Reduction
  • Picrates / metabolism
  • Polysorbates / chemistry
  • Reactive Oxygen Species / metabolism
  • Solubility
  • Surface-Active Agents / chemistry

Substances

  • Antioxidants
  • Biphenyl Compounds
  • Emulsions
  • Picrates
  • Polysorbates
  • Reactive Oxygen Species
  • Surface-Active Agents
  • 1,1-diphenyl-2-picrylhydrazyl
  • Curcumin