Antimelanogenic activity of MHY384 via inhibition of NO-induced cGMP signalling

Exp Dermatol. 2016 Aug;25(8):652-4. doi: 10.1111/exd.12953. Epub 2016 Feb 26.

Authors

Affiliations

¹ Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Korea.
² Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Korea.
³ College of Pharmacy, Inje University, Gimhae, Gyeongnam, Korea.

PMID: 26799796
DOI: 10.1111/exd.12953

No abstract available

Keywords: CREB; MHY384; cGMP; melanogenesis; nitric oxide.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cyclic GMP / metabolism
Cyclic GMP-Dependent Protein Kinases / metabolism
Drug Evaluation, Preclinical
Melanins / metabolism*
Mice, Hairless
Nitric Oxide / metabolism*
Skin Lightening Preparations / pharmacology*
Skin Pigmentation / drug effects*
Thiazolidines / pharmacology*
Ultraviolet Rays

Substances

(2RS,4R)-2-(2,4-dihydroxyphenyl)thiazolidine-4-carboxylic acid
Melanins
Skin Lightening Preparations
Thiazolidines
Nitric Oxide
Cyclic GMP-Dependent Protein Kinases
Cyclic GMP