Abstract
Sepsis and SIRS (systemic inflammatory response syndrome) belong to a severe disease complex characterized by infection and/or a whole-body inflammatory state. There is a growing body of evidence that neutrophils are actively involved in sepsis and are responsible for both release of cytokines and phagocytosis of pathogens. The neutrophil level is mainly regulated by G-CSF, a cytokine and drug, which is widely used in the septic patient with neutropenia. This review will briefly summarize the role of neutrophils and the therapeutic effect of G-CSF in sepsis. We further suggest that targeting neutrophil function to modulate the balance between innate immunity and inflammatory injury could be a worthwhile therapeutic strategy for sepsis.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Acute-Phase Proteins / antagonists & inhibitors
-
Acute-Phase Proteins / genetics
-
Acute-Phase Proteins / immunology
-
Animals
-
Carrier Proteins / antagonists & inhibitors
-
Carrier Proteins / genetics
-
Carrier Proteins / immunology
-
Disease Models, Animal
-
Gene Expression Regulation
-
Granulocyte Colony-Stimulating Factor / genetics
-
Granulocyte Colony-Stimulating Factor / immunology
-
Granulocyte Colony-Stimulating Factor / therapeutic use*
-
Humans
-
Immunity, Innate / drug effects*
-
Membrane Glycoproteins / antagonists & inhibitors
-
Membrane Glycoproteins / genetics
-
Membrane Glycoproteins / immunology
-
Mice
-
NF-kappa B / genetics
-
NF-kappa B / immunology
-
Neutrophils / drug effects*
-
Neutrophils / immunology
-
Neutrophils / pathology
-
Phagocytosis / drug effects
-
Sepsis / drug therapy*
-
Sepsis / genetics
-
Sepsis / immunology
-
Sepsis / pathology
-
Systemic Inflammatory Response Syndrome / drug therapy*
-
Systemic Inflammatory Response Syndrome / genetics
-
Systemic Inflammatory Response Syndrome / immunology
-
Systemic Inflammatory Response Syndrome / pathology
-
Toll-Like Receptor 4 / genetics
-
Toll-Like Receptor 4 / immunology
-
Tumor Necrosis Factor-alpha / antagonists & inhibitors
-
Tumor Necrosis Factor-alpha / genetics
-
Tumor Necrosis Factor-alpha / immunology
Substances
-
Acute-Phase Proteins
-
Carrier Proteins
-
Membrane Glycoproteins
-
NF-kappa B
-
TLR4 protein, human
-
Toll-Like Receptor 4
-
Tumor Necrosis Factor-alpha
-
lipopolysaccharide-binding protein
-
Granulocyte Colony-Stimulating Factor